Chronic myeloproliferative disorders

What are chronic myeloproliferative disorders?
Chronic myeloproliferative disorders are a group of slow-growing cancers in which too many blood cells (red blood cells, white blood cells or platelets) are produced by the bone marrow. The extra blood cells inhibit the rest of the blood cells in functioning properly. Chronic myeloproliferative disorder can sometimes become acute leukemia when too many abnormal white blood cells are produced.

There are six types of myeloproliferative disorders:
• Chronic myelogenous leukemia
• Polycythemia vera
• Primary myelobrosis
• Essential thrombocythemia
• Chronic neutrophilic leukemia
• Chronic eosinophilic leukemia
What causes chronic myeloproliferative disorders?
The causes of chronic myeloproliferative disorders are unknown, and there are no known risk factors. It typically occurs in people over age 50.
How are myeloproliferative disorders diagnosed?
At KHCC, physicians use a variety of diagnostic procedures and techniques to ensure the most accurate diagnosis possible, including:
• Complete blood count (CBC) test and other blood tests
• Peripheral blood smear to check for any abnormalities in the shape or maturity of the blood cells
• Bone marrow aspiration or biopsy to examine the bone marrow for abnormalities
• Cytogenetic analysis to look for changes in the chromosomes of blood or bone marrow cells
How are myeloproliferative disorders treated at KHCC?
The treating physician will present the case to the MDC panel who will determine the right treatment for the patient depending on how much the cancer has spread throughout the body.

There are different types of treatment for myeloproliferative disorders, depending on the disease itself and the condition and general health of the patient. Treatment for patients with myeloproliferative disorders can include chemotherapy, blood transfusions, surgery (to remove an enlarged spleen, stem cell transplants, phlebotomy (in which blood is taken from the body), biologic therapy and careful observation and waiting.
At KHCC, patients with myeloproliferative disorders receive top quality care through a multidisciplinary team of specialists highly experienced in treating blood disorders .

Supportive Care
The leukemia & MDS multidisciplinary clinic works in close cooperation with other departments at KHCC so that patients with myeloproliferative disorders can receive the most comprehensive care possible. Supportive care services at KHCC include: